L-tryptophan, GABA, Stevia, & Kava

amethyst98 · Post by **amethyst98** » Fri Feb 06, 2004 1:32 pm

Here is some information on L-tryptophan, GABA, Stevia, and Kava. The main point here is that just because something is �natural� it does not mean it is safe or effective. I want to emphasize again that dietary supplements do NOT need to be approved by the FDA for safety and effectiveness before they are sold to the consumer. Additionally, manufacturers and distributors of dietary supplements are NOT required by law to record, investigate, or forward any reports of injuries or illness from use of their product to the FDA (<A HREF="http://www.cfsan.fda.gov/~dms/ds-oview.html" TARGET=_blank>http://www.cfsan.fda.gov/~dms/ds-oview.html</A>).

L-tryptophan:
<A HREF="http://www.quackwatch.org/01QuackeryRel ... rypto.html" TARGET=_blank>http://www.quackwatch.org/01QuackeryRel ... to.html</A>
<A HREF="http://www.cfsan.fda.gov/~dms/ds-prod.html#try" TARGET=_blank>http://www.cfsan.fda.gov/~dms/ds-prod.html#try</A>

GABA:
*pay attention to the fact that GABA supplements are NOT recommended
<A HREF="http://my.webmd.com/content/article/73/ ... 31713CA348}" TARGET=_blank>http://my.webmd.com/content/article/73/ ... 3CA348}</A> --GABA

Stevia: <A HREF="http://www.quackwatch.org/04ConsumerEdu ... tevia.html" TARGET=_blank>http://www.quackwatch.org/04ConsumerEdu ... ia.html</A>

Kava: <A HREF="http://www.cfsan.fda.gov/~dms/addskava.html" TARGET=_blank>http://www.cfsan.fda.gov/~dms/addskava.html</A>

Orthomolecular Therapy: <A HREF="http://www.quackwatch.org/01QuackeryRel ... ortho.html" TARGET=_blank>http://www.quackwatch.org/01QuackeryRel ... ho.html</A>

Appropriate uses of dietary supplements: <A HREF="http://www.quackwatch.org/03HealthPromo ... ments.html" TARGET=_blank>http://www.quackwatch.org/03HealthPromo ... ts.html</A>

sunset34 · Post by **sunset34** » Fri Feb 06, 2004 2:53 pm

While there are over-the-counter GABA supplements available at most health foods -- sold as an insomnia remedy -- Doghramji advises against them.

Doghramji may not recommend GABA supplements but there are many that do.

From the sounds of this article, they are working on creating other GABA-stimulating drugs. This is good news for all of us concerned. I believe if they can develop a safer, more comfortable medication with virtually no side effects such as GABA supplements, more people would find satisfaction in treatment and the involvement of their doctors.

Just my thoughts.

sunset34 · Post by **sunset34** » Fri Feb 06, 2004 2:54 pm

Ps) have you found anything on L-Theanine? Just curious.

amethyst98 · Post by **amethyst98** » Fri Feb 06, 2004 8:01 pm

Hello Sunset:
Refer to this quote from the GABA article:
"While there are over-the-counter GABA supplements available at most health foods -- sold as an insomnia remedy -- Doghramji advises against them.

We just don't have any data on them. We do not know how much GABA is really in the supplement or the product's purity. There are no studies backing up the claims made by the supplement manufacturers."

Again, I think there are many people who would not want to be a guinea pig, so this information may be of use to them. But if you disagree, it doesn't matter to me. It is your body and your choice.
Yes, I agree it is great that research is progressing and finding more and more treatments for problems. It is amazing how far we have come on treating illness that once killed people or really disrupted their lives.
I will look up the L-theanine for you and get back to you on that. Thanks for your interest.

Guest · Post by **Guest** » Sat Feb 07, 2004 5:26 am

Amethyst,
I don't understand why you are taking numerous things from posts we have shared on the book "Breaking the Grip of Dangerous Emotions" and going out finding "info" to contradict what we have shared.
We are intelligent people here. I believe we can do our own research. Again even Lucinda Bassett has highly recommended this book and the research and information Dr. Janet has shared.
To balance this thread, here are a few sites that others can look through if interested.
Myths of supplemental safety. <A HREF="http://www.supplementinfo.org/industry/myths.htm" TARGET=_blank>http://www.supplementinfo.org/industry/myths.htm</A>
FDA approval? <A HREF="http://www.fdareview.org/harm.shtml" TARGET=_blank>http://www.fdareview.org/harm.shtml</A>
FDA and Stevia. <A HREF="http://www.stevia.net/fda.htm" TARGET=_blank>http://www.stevia.net/fda.htm</A>

amethyst98 · Post by **amethyst98** » Sat Feb 07, 2004 8:37 am

Grateful:
You're the only one who seems to think you have to go "balance" someone elses thread. I think this is quite arrogant on your part. Again, as I have said before other members have shown interest in information on topics that I have knowledge on. You are trying to control what others say. That is not right.
I'm glad you have found something you feel works for you. To think that I have just begun researching information about what YOU are reading is really believing that things revolve around yourself. The true fact is that I have been researching this kind of stuff for many years now. When I saw that there was a section on Nutrition I thought I really could make a difference in this area by sharing what I do know and my philosophy on life.
I ask that you not try to "balance" anyone else's posts. Anyone can start their own post. Things are not just about you.
I know my post has been helpful to some people, whether they have spoken up or not. Nothing you say to me is going to change what I do, because I know that what I am doing is good and has a benefit. Stop wasting your time trying to control what I say. It is not going to get you anywhere here, or in life in general. I ask that you and others stop this type of arguing and "balancing" because it is ridiculous.
One last thing. Just because Lucinda advocates something doesn't mean it is right. While I think her book was great and very helpful, I totally disagree with her take on supplements and nutrition. But that is ok. Don't do an "all-or-nothing" distortion. You can accept some of what someone says and think it is very valuable information, and then disregard other things. That is actually a much better way of doing things. It makes you think for yourself.
I hope this clears up my end.

sunset34 · Post by **sunset34** » Sat Feb 07, 2004 9:50 am

Amethyst,

I must say that the portrait you painted of Grateful is totally incorrect. She cares very much about EACH and every individual here in the forum and she is trying to protect the very truths she has personally learned about supplements she is taking and I can't say that I blame her for telling you how she feels.

It is one thing to join a discussion on something like GABA and inform everyone of the dangers or concerns of certain products within the discussion but to create a separate folder just to PROTEST the very things that have been very helpful to many people seems totally wrong in my opinion.

If you want to be helpful, why not share what you know in the post it's being discussed in ?

You seem to have this idea that if we don't agree with your view that we shouldn't post in your thread but this is a public forum available to everyone with different opinions and views.
Grateful had every right to share the other side of the topic and her views.

You are welcome to share what you know, but at the same time, we are welcome to share what we know.... let's allow the reader to determine what's right in their own mind. Seriously, the only way a reader can do that is by reading the PRO'S and the CON'S.

Grateful isn't the only one that believes threads should be "balanced". Things should never be one sided. People should be able to share everything they know, think, feel or believe. We are all so different and hearing everyone's views and beliefs is being "balanced" and "healthy".

It does seem as though you are going around "protesting" the very subjects we have been discussing. Almost like posting forum Billboards. Why not just share your links in the discussions that are being held? That way you are being heard and readers can investigate the links you share within PUBLIC group forum discussions?

A couple years back when I began posting here in this forum, I posted threads hoping to only hear from those that agreed with me. It didn't take long to learn that the forum doesn't work that way. It's a PUBLIC forum where everyone can share and it's unrealistic to expect people who disagree to stay out the discussion.

amethyst98 · Post by **amethyst98** » Sat Feb 07, 2004 10:13 am

Sunset:
I'm not trying to attack Grateful I was just responding to an attack I thought she was engaging in. I have NO problem with her sharing her information, but it was the way she said it that bothered me.
I assumed that the best way to share my information was to share it in my own post because I figured that you and grateful would not appreciate me "interrupting" any of your discussions (I don't think you are interrupting me, I just assummed from the fish for depression post that you did not appreciate me putting my input into your posts).
I haven't had a problem with how you have been sharing in my posts lately. Your tone completely changed and you were engaging in what I felt was a much better conversation.
Making comments like "In order to balance out the post" is to imply you have to go take care of a problem. Instead of just sharing.
When people ask me to stop sharing then that is trying to control what I say. I don't want to control what you say because frankly, I don't care.
Anyways, Sunset I don't have a problem with you I think we have gotten on the same page. I did not appreciate the remarks Grateful made that is all. I don't have a personal opinion of Grateful, I don't know her. But I did have a problem with what she said to me so I wanted to respond.
Let's not get in a back in forth again

. I just think making little remarks is impolite. I will continue to share my point of view without making it personal, I expect the same from everyone else. So as I have said before, continue to share your information like you do in the book discuss I think that is energy well spent. But you all have to understand that what I am doing is beneficial too and is again, not an attack on anyone.
If after reading this, you conclude that you would like me to share in your discussions, let me know. I can do this. However, it is still my decision where I post the information. This is not yours to determine and I don't think you should control this. If you want to share in my posts, that is fine with me too, but refrain from the statements about how I am disruptive and have horrible intentions.

SuzanneMarie · Post by **SuzanneMarie** » Sat Feb 07, 2004 10:24 am

Hopefully, some objective info on GABA...

GABA (Gamma-Amino Butyric Acid)
What does it do?
GABA is a natural calming and anti-epileptic agent in the brain that is manufactured from the amino acid glutamine and glucose.

Since GABA does not cross the blood-brain barrier very well (i.e., it cannot be transported efficiently into the brain from the bloodstream), virtually all of the GABA found in the brain is manufactured there.1 For that reason, supplemental GABA would not be expected to increase levels of GABA in the brain. Two doctors have reported that GABA is beneficial in the treatment of a variety of brain disorders, including epilepsy and schizophrenia.2 However, those reports have not been substantiated with clinical trials. High intake of GABA was shown to produce a significant increase in plasma growth-hormone levels (single administration of 5,000 mg) and prolactin (daily administration of 18,000 mg for four days) in one human study3 but the clinical significance of these observations is not clear.

Where is it found?
GABA is found as a nutritional supplement, primarily in capsules and tablets.

Who is likely to be deficient?
Some people with anxiety, panic disorders, and depression may not manufacture sufficient levels of GABA.

How much is usually taken?
Some doctors recommend GABA in the amount of 200 mg four times daily.

Are there any side effects or interactions?
The safety of GABA supplementation has not been demonstrated in human trials.

At the time of writing, there were no well-known drug interactions with GABA.

--------------------------------------------------------------------------------
References:
1. Waagepetersen HS, Sonnewald U, Schousboe A. The GABA paradox: multiple roles as metabolite, neurotransmitter, and neurodifferentiative agent. J Neurochem 1999;73:1335-42.

2. Braverman E, Pfieffer C. The Healing Nutrients Within. In Facts, Findings and New Research on Amino Acids. New Canaan, CT: Keats Publishing, 1987.

3. Cavagnini F, Invitti C, Pinto M. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol 1980;93:149-54.

Also, I read through the links you posted on Stevia and they're very vague as to why the FDA hasn't approved Stevia as a sugar substitute

Although no harm to humans has been documented, laboratory studies have raised questions about its safety [1].

There is nothing further as to what kinds of studies and what the findings were. I have been using it for a while, as I feel it is a 'safer' alternative to the chemicals found in other sugar substitutes. Just my two cents.

amethyst98 · Post by **amethyst98** » Sat Feb 07, 2004 10:55 am

Hi SuzzaneMarie:
Thanks for sharing. You provided very helpful information. Explains it well. Thanks.
I don't know a whole lot about Stevia, but I thought I would just share that link with you (I happened to run across it while looking over that website). What it sounds like to me is that the safety hasn't fully been determined. That is all I got out of that. I agree that the article was a bit vauge (could have been better). I just noticed you were taking Stevia and thought it might be helpful. That is all. It sounds like their understanding of Stevia is vague. Glad you are weighing your options that is my goal with this.

Thanks for reading the posts. I hope you found it helpful.